In this study, I intend to find the meeting point between Lee Woo-cheol's Soregen technology and Shipov's physical vacuum theory within the system of God science. In the case of Soregen technology, we have discovered that its principle of action can be understood more systematically and logically when reexamined from the perspective of the epistemology of Unification Thought. This shows that this can be an example of the scientific empirical application of epistemology. In the case of physical vacuum theory, I focused on the Shipov's book A Theory of Physical Vacuum. His seven-step reality, in particular, describes God and His created world by the generalized equations (A, B). Describing God, superconsciousness, and the natural world as special cases of the generalized equation is an ambitious attempt to describe the Creator and the world of all things with a unified equation. However, there is lack of sufficient discussion on the interrelationship between God, human beings, and all things (Heaven, Earth and Humankind) in only this book and it remains as a research project in the future. From the point of view of God science, based on God’s Original Sung Sang(original information) and human consciousness, Soregen technology focuses on changing the characteristics of matters, such as the original information → human consciousness → spatial informatization → material change etc. On the other hand, the physical vacuum theory, based on God’s original Hyung Sang (prime energy and prime force, pre-energy), focuses on the creation of materials such as absolute emptiness → primary vacuum field → physical vacuum → elementary particles and objects etc. In other words, Soregen technology is concerned more with information and the physical vacuum theory focuses more on energy (field). This study examines the possibility of the unification of Soregen technology and the physical vacuum theory from six perspectives; the First Cause and creation; Original Sung Sang and Original Hyung Sang; the relationship between human consciousness and matter; spatialization of information; and relativity, give-and-receive action, origin-division-union action, the four-position foundation, and the Three Great Blessings. Soregen technology and the physical vacuum theory both are based on the existence and creation of God, the First Cause of all things. Therefore, Soregen technology and the physical vacuum theory can understand and approach nature and all things as one unified subject from the perspective of the ideal of creation, purpose of creation, and the laws of creation.